An isoform-selective stabilizer of the circadian clock protein CRY2. Dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. Has been used in combination with CRY1 stabilizer KL101 to demonstrate the differential gatekeeper conformations of the two proteins....
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An isoform-selective stabilizer of the circadian clock protein CRY2. Dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. Has been used in combination with CRY1 stabilizer KL101 to demonstrate the differential gatekeeper conformations of the two proteins. TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics
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