Aquaporin 4 channel blocker, IC50 = 3.1 μM. Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI. Increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice. Reduces brain edema when administered after onset of ischemia in rat models
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Aquaporin 4 channel blocker, IC50 = 3.1 μM. Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI. Increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice. Reduces brain edema when administered after onset of ischemia in rat models
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