Thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs). Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition. Reduces production of IL-18 and caspase-1...
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Thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs). Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition. Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages
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