Agonist of the orphan nuclear receptors RORα and RORγ. It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian stabilizing loop. SR1078 stimulation of RORα restored clock protein BMAL1 expression and oscillation and blocked...
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Agonist of the orphan nuclear receptors RORα and RORγ. It attenuated intrapancreatic pathological changes in mouse models of chronic pancreatitis via restoration of the circadian stabilizing loop. SR1078 stimulation of RORα restored clock protein BMAL1 expression and oscillation and blocked MYCN-mediated neuroblastoma growth. It reduced repetitive behavior is a mouse model of autism suggesting aq potential therapeutic pathway for the disorder. SR1078 treatment lead to an increase in p53 levels and increased apoptosis in HepG2 cells
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