Potent and selective leukocyte elastase inhibitor, IC50 = 44 nM. Displays no activity at a variety of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil migration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and...
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Potent and selective leukocyte elastase inhibitor, IC50 = 44 nM. Displays no activity at a variety of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil migration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo
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