Siramesine (Lu 28-179) is a σ2 selective agonist (IC50’s: σ1 = 17nM, σ2 = 0.2nM). It produced non-sedating potent and long-last anxiolytic effects in rodents. Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal...
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Siramesine (Lu 28-179) is a σ2 selective agonist (IC50’s: σ1 = 17nM, σ2 = 0.2nM). It produced non-sedating potent and long-last anxiolytic effects in rodents. Siramesine induced caspase-independent programmed cell death in various cancer cell lines via increased levels of ROS and lysosomal leakage. Mitochondrial destabilization via loss of membrane potential and increased ROS has also been offered as a mechanism of action for the triggering of cell death by Siramesine
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