Manufactured by:TriBio Science
RUO

SBI-0206965, ULK1 inhibitor

A potent and selective inhibitor of the autophagy kinase ULK-1, IC50=108 and 711 nM for ULK1 and 2 respectively. Suppresses autophagy induced by mTOR inhibitors and thus synergizes with mTOR inhibitors to induce apoptosis and cell death in tumor cells

SKU:
ABM148712-1
Manufacturer SKU
TBI1623-25MG | TBI1623-5MG
Product type
Biochemical Inhibitors
TargetULK1
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

A potent and selective inhibitor of the autophagy kinase ULK-1, IC50=108 and 711 nM for ULK1 and 2 respectively. Suppresses autophagy induced by mTOR inhibitors and thus synergizes with mTOR inhibitors to induce apoptosis and cell death in tumor cells

Key facts & specifications
Also known as
2-((5-Bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide
Molecular weight
489.32
Form / buffer
powder
Activity
A potent and selective inhibitor of the autophagy kinase ULK-1, IC50=108 and 711 nM for ULK1 and 2 respectively. Suppresses autophagy induced by mTOR inhibitors and thus synergizes with mTOR inhibitors to induce apoptosis and cell death in tumor cells.
Molecular formula
C 21 H 21 BrN 4 O 5
Solubility
Soluble in DMSO (up to 30 mg/ml)
Technical note
Stability: ≥ 1 year.
Identifiers & database references
Manufacturer SKU
TBI1623-25MG | TBI1623-5MG
CAS number
1884220-36-3
Storage, stability & shipping
Storage conditions
-20°C
Shipped at
4°C
Long-term storage
-20°C
Compliance & documents
Datasheet
Open datasheet
Safety data sheet
Open SDS
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

Research target context

ULK1unc-51 like autophagy activating kinase 1

View target guide

ULK1 identifies unc-51 like autophagy activating kinase 1 in Homo sapiens (Human). This target record connects NCBI Gene 8408, UniProtKB O75385 and related ABMIUM catalogue products.

Organism
Homo sapiens (Human)
NCBI Gene
8408
UniProtKB
O75385
TriBio Science
£425.00