Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA. IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages and ~0.80 µM in wild type human THP-1 cells. It is selective for cGAS with no targeting of IFNB1 protein,...
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Inhibitor of cyclic GMP-AMP synthase (cGAS), an important innate immune system sensor of foreign cytoplasmic double-stranded DNA. IC50 = 0.70 µM in dsDNA-stimulated RAW macrophages and ~0.80 µM in wild type human THP-1 cells. It is selective for cGAS with no targeting of IFNB1 protein, interferon receptors, or downstream signaling components of the JAK/STAT pathway. RU.521 was able to significantly increase cardiac output in a mouse model of sepsis. Active in both mouse and human cell lines
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