RNase A (Ribonuclease A) is a single chain polypeptide with 4 disulfied bridges. It is an endoribonuclease that specifically cleaves single stranded RNA at C and U residues. It cleaves the phosphodiester bond between the 5’ribose of a nucleotide and the phosphate group attached to the 3′-ribose...
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RNase A (Ribonuclease A) is a single chain polypeptide with 4 disulfied bridges. It is an endoribonuclease that specifically cleaves single stranded RNA at C and U residues. It cleaves the phosphodiester bond between the 5’ribose of a nucleotide and the phosphate group attached to the 3′-ribose of an adjacent pyrimidine nucleotide. The resulting 2′, 3′-cyclic phosphate is hydrlized to the corresponding 3′-nucleoside phosphate
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