A potent and selective GPR18 antagonist (IC50 = 0.279 µM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2. Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of...
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A potent and selective GPR18 antagonist (IC50 = 0.279 µM) exhibiting >36-fold selectivity against GPR55 and CB1 and 14-fold selectivity against CB2. Inhibits N-arachidonylglycine-induced acrosomal exocytosis in human spermatozoa indicating that GPR18 may be involved in physiological processes of human spermatozoa
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