Mutant p53, along with family members p63 and p73, are forced into wild-type conformation by PRIMA-1MET, thus restoring their tumor suppressor function. In addition to reactivating p53-dependent apoptosis, it blocks p73-dependent colony formation and migration of multiple myeloma cells. It also...
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Mutant p53, along with family members p63 and p73, are forced into wild-type conformation by PRIMA-1MET, thus restoring their tumor suppressor function. In addition to reactivating p53-dependent apoptosis, it blocks p73-dependent colony formation and migration of multiple myeloma cells. It also causes tumor cell death independent of p53, via glutathione depletion and ROS production
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