Oxaprozin is a clinically useful non-steroidal anti-inflammatory drug. In addition to typical NSAID COX inhibition, Oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-kappaβ pathway. The compound is capable of inhibiting both anandamide hydrolase in neurons...
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Oxaprozin is a clinically useful non-steroidal anti-inflammatory drug. In addition to typical NSAID COX inhibition, Oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-kappaβ pathway. The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 µmol/l), with consequent potent analgesic activity, and NF-kappaB activation in inflammatory cells (IC50 = 50 µmol/l)
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