A potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models. Inhibits vascular inflammation in vivo. Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling. Inhibits migration, invasion and adhesion...
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A potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models. Inhibits vascular inflammation in vivo. Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling. Inhibits migration, invasion and adhesion of melanoma cells. Induces apoptosis in osteosarcoma cells by multiple pathways
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