A highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. In a genetically engineered mouse model for BRCA1-associated breast cancer olaparib inhibited tumor growth and improved survival with no signs of toxicity. Synergizes with many...
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A highly potent and selective PARP-inhibitor with IC₅₀ values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. In a genetically engineered mouse model for BRCA1-associated breast cancer olaparib inhibited tumor growth and improved survival with no signs of toxicity. Synergizes with many other anticancer agents. Shows efficacy in colorectal cancers. Prevents house dust mite allergen-induced asthma in a mouse model
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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PARP1 identifies poly(ADP-ribose) polymerase 1 in Homo sapiens (Human). This target record connects NCBI Gene 142, UniProtKB P09874 and related ABMIUM catalogue products.
