A remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Suppresses JAK2-V617F-mediated human pathological cell growth in vitro and in vivo and is concomitant with the disruption of intracellular vimentin filaments. Reduces the tumorigenic potential of T98G glioblastoma cells in vitro...
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A remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Suppresses JAK2-V617F-mediated human pathological cell growth in vitro and in vivo and is concomitant with the disruption of intracellular vimentin filaments. Reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo
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JAK2 identifies Janus kinase 2 in Homo sapiens (Human). This target record connects NCBI Gene 3717, UniProtKB O60674 and related ABMIUM catalogue products.
