Endogenous conjugate of arachidonic acid and dopamine. May be the “endogenous capsaicin like substance” in the CNS acting at TRPV1 channels, EC50~ 50 nM1. Also acts as a selective cannabinoid CB1 agonist (Ki=0.25 and 15 μM for CB1 and CB2 respectively) and results in a distinct signaling profile...
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Endogenous conjugate of arachidonic acid and dopamine. May be the “endogenous capsaicin like substance” in the CNS acting at TRPV1 channels, EC50~ 50 nM1. Also acts as a selective cannabinoid CB1 agonist (Ki=0.25 and 15 μM for CB1 and CB2 respectively) and results in a distinct signaling profile from any known cannabinoid. Competitive inhibitor of FAAH and anadamide transport. Modulates acute systemic inflammation via non-hematopoietic TRPV1
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