Myriocin is a fungal metabolite with potent immunosuppressant activity. It inhibits serine palmitoyltransferase (K i = 0.28 nM) blocking the synthesis of ceramide. It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2 /M phase through decreased sphingolipid levels...
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Myriocin is a fungal metabolite with potent immunosuppressant activity. It inhibits serine palmitoyltransferase (K i = 0.28 nM) blocking the synthesis of ceramide. It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2 /M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression
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