ML277 is a potent (EC 50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG). ML277 enhances cardiac delayed rectifier K + currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential...
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ML277 is a potent (EC 50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG). ML277 enhances cardiac delayed rectifier K + currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome. It displayed cardioprotective effects against ischemia in cellular and whole-heart models
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