ML210 inhibits glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron-catalyzed formation of free radicals from lipid peroxides. Exposure of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state to ML210 resulted...
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ML210 inhibits glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron-catalyzed formation of free radicals from lipid peroxides. Exposure of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state to ML210 resulted in selective induction of ferroptosis. ML210 is selectively lethal to HRAS g12v expressing cells (IC 50 = 7.1 nM for BJeLR cells) compared to isogenic cells without HRAS g12v (IC 50 = 272 nM for BJeH-LT cells). LUHMES dopaminergic neurons are highly susceptible to ML210-induced ferroptosis
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