Ferroptosis suppressor protein (FSP1) inhibitor Down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase). The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme. It is a...
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Ferroptosis suppressor protein (FSP1) inhibitor
Down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase). The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme. It is a useful pharmacological agent for lowering sphingolipid levels in cells as well as in animal models. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence
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