Inhibits constitutive and inducible HSP70 expression in non-stressed and heat-stressed cancer cells. Blocks geldanamycin-induced induction of HSP70 and inhibition of TGFß signaling. Inhibits leukocyte integrin α4ß7-mediated adhesion of T cells to mucosal addressin cell adhesion molecule 1...
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Inhibits constitutive and inducible HSP70 expression in non-stressed and heat-stressed cancer cells. Blocks geldanamycin-induced induction of HSP70 and inhibition of TGFß signaling. Inhibits leukocyte integrin α4ß7-mediated adhesion of T cells to mucosal addressin cell adhesion molecule 1 (MAdCAM-1), suggesting that HSP70 is essential for ß7 integrin signalling. Suppresses morphine analgesic tolerance in a rodent model (100 mg/Kg)
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HSPA1A identifies heat shock protein family A (Hsp70) member 1A in Homo sapiens (Human). This target record connects NCBI Gene 3303, UniProtKB P0DMV8 and related ABMIUM catalogue products.
