Inhibits HIF-1α (IC50 = 20 µM in a HIF-reporter cell line). It suppresses mTORC1 phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K), thereby down-regulating translation of HIF-1α transcripts into protein1. It shows marked...
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Inhibits HIF-1α (IC50 = 20 µM in a HIF-reporter cell line). It suppresses mTORC1 phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K), thereby down-regulating translation of HIF-1α transcripts into protein1. It shows marked dose-response cytotoxicity (IC50 = 15 – 25 µM) in cancer cell lines such as MCF7 and A5491. Decreases viability of epidermal stem cells in a wound healing model. Treatment with 10 μM KC7F2 significantly reduced NKCC1, but not NFAT5, expression in hippocampal neurons in a model of hypoxia-ischemia
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