A sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 µM) acting via inhibition of IKKß6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression, iNOS expression and RANTES...
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A sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 µM) acting via inhibition of IKKß6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression, iNOS expression and RANTES biosynthesis. Displays protective effects in endotoxic shock in rodent models. Induces apoptosis in glioma cells
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