Specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export. When added to cells during mitosis it impairs the release of an importin-β cargo probe and causes defects in spindle assembly. Inhibition of importin-β...
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Specifically inhibits importin-β-mediated nuclear import without disrupting transportin-mediated nuclear import or CRM1-mediated nuclear export. When added to cells during mitosis it impairs the release of an importin-β cargo probe and causes defects in spindle assembly. Inhibition of importin-β function is most likely mediated by blocking its interaction with RanGTP. It is an important new tool to probe the function of the importin-β/RanGTP pathway. Cell permeable
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