Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8). Agonist at TRPM8 (EC50 = 0.2 µM) and ANKTM1(TRPA1). Agonist effects require Ca2+ and are pH dependent. Icilin induced...
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Icilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8). Agonist at TRPM8 (EC50 = 0.2 µM) and ANKTM1(TRPA1). Agonist effects require Ca2+ and are pH dependent. Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death
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