Modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC 50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC 50 = 1 nM)) and Aiolos (IKZF3; EC 50 = 0.5 nM). It is more specific for the cereblon complex...
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Modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC 50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC 50 = 1 nM)) and Aiolos (IKZF3; EC 50 = 0.5 nM). It is more specific for the cereblon complex and does not degrade GSPT1 of CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells. Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE). It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells
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