Potent and selective inhibitor of MEK. Acts via covalent binding to Cys residue. In cells, hypothemycin inhibits the MEK-ERK axis with sufficient selectivity to normalize transformed phenotypes. Inhibits TNFα production in LPS-stimulated macrophages
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Potent and selective inhibitor of MEK. Acts via covalent binding to Cys residue. In cells, hypothemycin inhibits the MEK-ERK axis with sufficient selectivity to normalize transformed phenotypes. Inhibits TNFα production in LPS-stimulated macrophages
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MDK identifies midkine in Homo sapiens (Human). This target record connects NCBI Gene 4192, UniProtKB P21741 and related ABMIUM catalogue products.
