Inhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC 50 =8.9 nM in human renal microsomes). It displays neuroprotective effects in a rat model of traumatic brain injury via inhibition of neuronal pyroptosis. It...
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Inhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC 50 =8.9 nM in human renal microsomes). It displays neuroprotective effects in a rat model of traumatic brain injury via inhibition of neuronal pyroptosis. It attenuates cerebral ischemia-reperfusion injury as well as oxidative injury and peripheral nerve damage in type-2 diabetic mice. It alleviates myocardial oxidative stress and restores endothelial function, suggesting therapeutic potential in obesity-associated vascular disease
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