Gilteritinib is a potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants. It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake...
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Gilteritinib is a potent inhibitor of FLT3 (IC50 = 5 nM, wild-type FLT3) with more potent activity against all FLT3 mutants. It also potently inhibits Axl (IC50 = 41 nM). Clinically useful in the treatment of acute myeloid leukemia. Gilteritinib has also been shown to inhibit glutamine uptake and utilization via downregulation of glutamine transporters
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FLT3 identifies fms related receptor tyrosine kinase 3 in Homo sapiens (Human). This target record connects NCBI Gene 2322, UniProtKB P36888 and related ABMIUM catalogue products.
