GC376 inhibits the 3C protease of poliovirus with an IC50 of 1.77 µM, foot-and-mouth disease virus (FMDV) with an IC50 of 1.16 µM, and human rhinovirus (HRV) with an IC50 of 0.2 µM. It also targets the 3C-like proteases of Norwalk virus, MD145 virus, transmissible gastroenteritis virus (TGEV),...
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GC376 inhibits the 3C protease of poliovirus with an IC50 of 1.77 µM, foot-and-mouth disease virus (FMDV) with an IC50 of 1.16 µM, and human rhinovirus (HRV) with an IC50 of 0.2 µM. It also targets the 3C-like proteases of Norwalk virus, MD145 virus, transmissible gastroenteritis virus (TGEV), and SARS-CoV, with IC50 values of 0.49 µM, 0.96 µM, 0.82 µM, and 4.35 µM, respectively
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