Long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM. Allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Clinically useful agent for symptomatic relief of Alzheimer’s disease but fails to...
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Long-acting, centrally active acetylcholinesterase inhibitor, IC50 = 410 nM. Allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Clinically useful agent for symptomatic relief of Alzheimer’s disease but fails to prevent progression of the disease
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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ACHE is acetylcholinesterase (Yt blood group), encoding acetylcholinesterase (AChE). This record links the verified human identity (NCBI Gene 43; UniProt P22303) and established Yt blood-group context to ABMIUM catalogue products.
Biological function: Acetylcholinesterase (ACHE/AChE) rapidly hydrolyses acetylcholine to terminate cholinergic signal transmission at neuromuscular junctions and brain cholinergic synapses. ACHE protein is also present on red-blood-cell membranes, where it constitutes the Yt blood group antigen.
