Vitamin A (retinoic acid) analog that induces apoptosis in cancer cell lines via RAR-dependent and -independent mechanisms. Agonist for RARs, but with mixed response pattern, believed to be the reason for its low toxicity. Also inhibits dihydroceramide desaturase (IC50 = 2.3 µM), preventing...
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Vitamin A (retinoic acid) analog that induces apoptosis in cancer cell lines via RAR-dependent and -independent mechanisms. Agonist for RARs, but with mixed response pattern, believed to be the reason for its low toxicity. Also inhibits dihydroceramide desaturase (IC50 = 2.3 µM), preventing obesity, hyperglycemia, insulin resistance and hepatic steatosis in mice. Inhibits Zika virus infection by interfering with the ZIKV NS5 / importin α/β1 heterodimer interaction and blocking nuclear import. Induces reactive oxygen species (ROS) production and NF-κB inhibition in FLT3-mutated AML cells
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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