Rho-associated kinase inhibitor (IC50 = 1.9 µM and 10.7 µM for Rho-associated kinase II and Rho-associated kinase respectively). Inhibits other kinases including cyclic nucleotide-dependent protein kinases. Reduces tryptamine-evoked vasopressor responses. attenuates bleomycin-induced pulmonary...
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Rho-associated kinase inhibitor (IC50 = 1.9 µM and 10.7 µM for Rho-associated kinase II and Rho-associated kinase respectively). Inhibits other kinases including cyclic nucleotide-dependent protein kinases. Reduces tryptamine-evoked vasopressor responses. attenuates bleomycin-induced pulmonary fibrosis in a mouse model. Clinically useful vasodilator
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