A potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor...
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A potent and selective fatty acid synthase (FASN) inhibitor acting via interfering with cofactor binding
IC50s = 147 and 213 nM respectively for inhibition of acetate and glucose incorporation into total lipids in HepG2 cells. IC50=5.84 μM in an isolated enzyme assay. Displays potent antitumor activity in the MMTV-Neu HER2+ breast cancer model. Reduces HIV-1 virion production by 90% (EC50=213 nM)
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FASN identifies fatty acid synthase in Homo sapiens (Human). This target record connects NCBI Gene 2194, UniProtKB P49327 and related ABMIUM catalogue products.
