Elafibranor is a dual PPARalpha/delta agonist (EC50 PPARalpha = 10-20 nM; PPARdelta = 100-150 nM). Elafibranor’s antidiabetic effects in db/db were without the adverse cardiac effects seen in PPARgamma agonism. Elafibranor has also been shown to have therapeutic promise in the treatment of...
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Elafibranor is a dual PPARalpha/delta agonist (EC50 PPARalpha = 10-20 nM; PPARdelta = 100-150 nM). Elafibranor’s antidiabetic effects in db/db were without the adverse cardiac effects seen in PPARgamma agonism. Elafibranor has also been shown to have therapeutic promise in the treatment of nonalcoholic steatohepatitis (NASH)
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