Selective agonist at estrogen-related receptors ERRβ and ERRɣ with minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. Displays antiproliferative activity in prostate cancer cells. Promotes hormone production and cell fusion in cytotrophoblasts. In breast cancer cells DY131...
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Selective agonist at estrogen-related receptors ERRβ and ERRɣ with minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. Displays antiproliferative activity in prostate cancer cells. Promotes hormone production and cell fusion in cytotrophoblasts. In breast cancer cells DY131 arrests cells in G2/M and causes mitotic spindle defects. Inhibits osteoclastogenesis and protects against inflammatory bone loss induced by LPS in vivo
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