Potent estrogen ERβ receptor agonist. Displays a 70-fold selectivity over ERα, EC50 = 0.85 and 66 nM, respectively. Regulates expression of GluR1, 2 and 3 in rat hippocampus. Ameliorates portal hypertension in a carbon tetrachloride-induced liver cirrhosis rat model. Stimulates proliferation of...
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Potent estrogen ERβ receptor agonist. Displays a 70-fold selectivity over ERα, EC50 = 0.85 and 66 nM, respectively. Regulates expression of GluR1, 2 and 3 in rat hippocampus. Ameliorates portal hypertension in a carbon tetrachloride-induced liver cirrhosis rat model. Stimulates proliferation of androgen-independent prostate cancer cell line PC-3 via a novel pathway involving ERβ-mediated activation of β-catenin. A useful tool for elucidating the biological function of ERβ
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