A metal chelator with potent antitumor activity. Displays an average IC50 of 30 nM over 28 cancer cell lines (IC50 range 5 nM to 400 nM). Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones...
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A metal chelator with potent antitumor activity. Displays an average IC50 of 30 nM over 28 cancer cell lines (IC50 range 5 nM to 400 nM). Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones (KB3-1 epidermoid carcinoma cells) with an IC50 = 12 nM for both lines. The potency of Dp44mT has been attributed to the high redox activity of the Dp44mT-Fe complex leading to cytotoxic ROS generation. The antitumor activity of Dp44mT may also be mediated by a redox active copper complex that causes cellular glutathione depletion and lysosomal damage. It also inhibits T-cell activation and prevented CD25 up-regulation via a copper-dependent mechanism
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