Inhibits the mitochondrial Na + -Ca 2+ exchanger (NCX) in isolated heart mitochondria, IC 50 =0.36 μM. Does not inhibit the plasmalemmal NCX. Also inhibits voltage-gated Ca 2+ channels in intact cells and therefore its use in cellular studies must employ adequate controls. Prevents sudden death...
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Inhibits the mitochondrial Na + -Ca 2+ exchanger (NCX) in isolated heart mitochondria, IC 50 =0.36 μM. Does not inhibit the plasmalemmal NCX. Also inhibits voltage-gated Ca 2+ channels in intact cells and therefore its use in cellular studies must employ adequate controls. Prevents sudden death in a Guinea pig model of heart failure. Displays pronounced cytoprotective effects in chromaffin cells and in neuronal injury models. Blood-brain barrier permeant
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