CD38, also known as ADP-ribosyl cyclase, is a multifunctional ectoenzyme expressed in many immune cells including CD4+, CD8+, B lymphocytes and natural killer cells. It functions in cell adhesion, signal transduction and calcium signaling. CD38 is involved in the metabolism of nicotinamide...
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CD38, also known as ADP-ribosyl cyclase, is a multifunctional ectoenzyme expressed in many immune cells including CD4+, CD8+, B lymphocytes and natural killer cells. It functions in cell adhesion, signal transduction and calcium signaling. CD38 is involved in the metabolism of nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP). The results are the production of Ca2+-mobilizing compounds, such as cyclic ADP ribose (cADPR) and ADP ribose (ADPR). CD38 is used as a marker for poor prognosis in chronic lymphocytic leukemia and multiple myeloma and is an attractive cancer immunotherapy drug target
Tribioscience’s CD38 Assay Kit is a simple and fast fluorometric assay that measures the cyclase activity of CD38 in biological samples. CD38 catalyzes the conversion of nicotinamide guanine dinucleotide (NGD+) to cyclic GDP-ribose (cGDPR) which can be measured by fluorometric method at Ex/Em=300 nm/410 nm
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