Inhibits Class I PI3K isoforms [e.g. p110α (IC50 = 52 nM), p110δ (IC50 = 116 nM] but not Class III or IV [e.g. Vps34, mTOR, PI4Kβ]. Blocks or pauses glioma cell cycle at G2/M depending on p53 status. At 5 mg/kg, efficiently inhibits phosphorylation of PI3K target AKT Ser473 in mouse brains....
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Inhibits Class I PI3K isoforms [e.g. p110α (IC50 = 52 nM), p110δ (IC50 = 116 nM] but not Class III or IV [e.g. Vps34, mTOR, PI4Kβ]. Blocks or pauses glioma cell cycle at G2/M depending on p53 status. At 5 mg/kg, efficiently inhibits phosphorylation of PI3K target AKT Ser473 in mouse brains. Augments chaperone-mediated autophagy (CMA) in lysosomes isolated from mouse liver
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