Specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Blocks secretion and prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Inhibits guanine nucleotide-exchange proteins BIG1 and BIG2, activators of ADP-ribosylation factors. Induces apoptosis...
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Specific inhibitor of protein translocation from endoplasmic reticulum to Golgi. Blocks secretion and prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Inhibits guanine nucleotide-exchange proteins BIG1 and BIG2, activators of ADP-ribosylation factors. Induces apoptosis independently of p53. Activates sphingomyelin metabolism. Triggers Bip/Akt-regulated autophagy in colorectal cancer cells
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