BMS-309403 is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding protein aP2 (FABP4). BMS-309403 stimulated glucose uptake in myotubes via activation of AMPK. It decreased ER stress-associated inflammation in skeletal muscle and...
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BMS-309403 is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding protein aP2 (FABP4). BMS-309403 stimulated glucose uptake in myotubes via activation of AMPK. It decreased ER stress-associated inflammation in skeletal muscle and suppressed inflammation and oxidative stress in mouse and cell models of acute lung injury
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FABP4 identifies fatty acid binding protein 4 in Homo sapiens (Human). This target record connects NCBI Gene 2167, UniProtKB P15090 and related ABMIUM catalogue products.
Biological function: Fatty acid binding protein 4 (FABP4; A-FABP/aP2) is a cytoplasmic lipid-binding protein enriched in adipocytes that binds long-chain fatty acids and related hydrophobic ligands and participates in fatty-acid transport and metabolic signalling.
