BML283 is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) – AC50 = 111nM. PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and an increase in anabolic metabolism. BML283 is an important tool for studying the...
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BML283 is a selective activator of the Tumor Specific M2 Isoform of Pyruvate Kinase (PKM2) – AC50 = 111nM. PKM2 activity is downregulated in most cancer cells leading to a decrease in catabolic metabolism and an increase in anabolic metabolism. BML283 is an important tool for studying the effects of PKM2 and cancer metabolism
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