Potent inhibitor (IC50 = 2 nM) of the facilitative glucose transporter GLUT1, an enzyme frequently overexpressed in many cancers. It shows greater than 100-fold selectivity over GLUT2-4. BAY-876 displayed potent antitumor activity in ovarian cancer xenograft models and in triple negative breast...
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Potent inhibitor (IC50 = 2 nM) of the facilitative glucose transporter GLUT1, an enzyme frequently overexpressed in many cancers. It shows greater than 100-fold selectivity over GLUT2-4. BAY-876 displayed potent antitumor activity in ovarian cancer xenograft models and in triple negative breast cancer cells displaying high glycolytic and low oxidative phosphorylation rates. It reduced CD4+ T cell proliferation and IFN-γ secretion via GLUT1 inhibition suggesting utility against auto-inflammatory diseases. BAY-876 induces disulfidptosis in SLCA11high cancer cells
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SLC2A1 identifies solute carrier family 2 member 1 in Homo sapiens (Human). This target record connects NCBI Gene 6513, UniProtKB P11166 and related ABMIUM catalogue products.
