PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model. Induces apoptosis via...
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PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model. Induces apoptosis via PPARγ-independent mechanisms. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism. Increases osteoblastogenesis and bone mass in a mouse model. Active in vivo
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PPARG identifies peroxisome proliferator activated receptor gamma in Homo sapiens (Human). This target record connects NCBI Gene 5468, UniProtKB P37231 and related ABMIUM catalogue products.
