Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses joint inflammation in two distinct mouse models. Ameliorates surgical brain injury, colitis, intimal...
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Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses joint inflammation in two distinct mouse models. Ameliorates surgical brain injury, colitis, intimal hyperplasia-induced inflammatory processes and renal injury/fibrosis in rodent models. Orally active
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