Manufactured by:TriBio Science
RUO

AS-60524, PI 3-Kinase inhibitor

Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses joint inflammation in two distinct mouse models. Ameliorates surgical brain injury, colitis, intimal...

SKU:
ABM146638-1
Manufacturer SKU
TBI2575-25MG | TBI2575-5MG
Product type
Biochemical Inhibitors
TargetPI 3-Kinase
Purity>98%

Manufacturer provenance

Manufactured by:
TriBio Science
Sold by:
ABMIUM
Fulfilled from:
Manufacturer facility or confirmed fulfilment location

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Product description

Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses joint inflammation in two distinct mouse models. Ameliorates surgical brain injury, colitis, intimal hyperplasia-induced inflammatory processes and renal injury/fibrosis in rodent models. Orally active

Key facts & specifications
Also known as
5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione
Molecular weight
257.27
Form / buffer
powder
Activity
Potent and selective inhibitor of PI 3-kinase γ (PI 3-Kγ ), IC50 = 8 nM displaying 30-fold selectivity over PI 3-Kδ and PI 3-Kβ and 7.5-fold selectivity over PI 3-Kα. Suppresses joint inflammation in two distinct mouse models. Ameliorates surgical brain injury, colitis, intimal hyperplasia-induced inflammatory processes and renal injury/fibrosis in rodent models. Orally active.
Molecular formula
C 12 H 7 N 3 O 2 S
Solubility
Soluble in DMSO (up to 1.5 m g/ml with warming)
Technical note
Stability: ≥ 2 years.
Identifiers & database references
Manufacturer SKU
TBI2575-25MG | TBI2575-5MG
CAS number
648450-29-7
Storage, stability & shipping
Storage conditions
-20°C
Shipped at
4°C
Long-term storage
-20°C
Compliance & documents
Datasheet
Open datasheet
Safety data sheet
Open SDS
Frequently asked questions
Who manufactured this product?

This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.

Can ABMIUM ship this product internationally?

ABMIUM supports global orders. Availability, shipping requirements and applicable import arrangements are confirmed before fulfilment where required.

Can I check suitability before ordering?

Yes. Send your target, sample, application and experimental conditions through ABMIUM MATCH or technical support.

Is this product for clinical use?

Unless the listing expressly states otherwise, ABMIUM products are supplied for research use only and are not for diagnostic or therapeutic use.

TriBio Science
£311.00