Atypical retinoid that acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway. Downstream signaling results in an increase of LAMP-2A expression. Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress...
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Atypical retinoid that acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway. Downstream signaling results in an increase of LAMP-2A expression. Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model. AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease-modifying strategy in Parkinson’s disease. A targetome analysis of AR7-induced CMA in cancer cells has been performed
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