Adenosylhomocysteinase (AHCY) or S-adenosylhomocysteine hydrolase (SAHH) is an enzyme that catalyzes the reversible hydrolysis of S-Adenosyl Homocysteine (SAH) to adenosine and homocysteine (Hcy). In mammals, AHCY is the only enzyme capable of performing this reaction. SAH is the by-product and...
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Adenosylhomocysteinase (AHCY) or S-adenosylhomocysteine hydrolase (SAHH) is an enzyme that catalyzes the reversible hydrolysis of S-Adenosyl Homocysteine (SAH) to adenosine and homocysteine (Hcy). In mammals, AHCY is the only enzyme capable of performing this reaction. SAH is the by-product and a potent inhibitor of methyltransferase activity. AHCY deletion is embryonic lethal in many organisms (from plants to mammals). In humans, AHCY deficiency is associated with an incurable rare recessive disorder in methionine metabolism
Tribioscience’s AHCY Activity Assay utilizes SAH as the substrate to form homocysteine and adenosine. The free thiol group of the homocysteine can be detected with a thiol probe generating an enhanced fluorescent signal at Ex/Em = 400/465 nm. The assay principle is displayed in Figure 1. The kit provides the easiest and most accurate approach to measuring AHCY activity in a variety of samples
Fully tested in-house by ABMIUM, or supported by an advanced validation report from a partner reviewed by ABMIUM. Highest confidence. Non-conformities fully supported under the ABMIUM Product Promise.
Quality verified. Independent collaborator or expected-performance data available. Product meets ABMIUM quality standards.
Expected to work based on structural and biochemical data. Not yet directly tested by ABMIUM or a collaborator. No non-conformity support for this combination.
Not recommended for this application or species/sample combination. This may indicate either evidence of unsuitability or that the combination has not been tested and therefore cannot currently be recommended.
Sample compatibility evidence using the same validation key.
| Sample type | Sample compatibility |
|---|---|
| Plant material |
This product is manufactured by TriBio Science and sold through ABMIUM without relabelling.
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