α-Mangostin is a xanthone natural product that has historically been used in traditional folk medicine. It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING. Induces IFN- production and repolarizes human monocyte-derived M2 macrophages to...
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α-Mangostin is a xanthone natural product that has historically been used in traditional folk medicine. It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING. Induces IFN- production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage. Suppresses the metastasis of human renal carcinoma cells. Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells
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